This method shows to be able to predict occult metastases and select patients who would benefit from neck dissection (Fig. Conclusion: Although sentinel lymph node (SLN) biopsy is not yet validated for clinical use to replace elective neck dissection in patients with oral squamous cell carcinoma, it can be recommended for patients who do not fulfil the criteria for elective neck treatment according to current treatment protocols. Identification of the sentinel lymph node in patients with squamous cell carcinoma of the oral cavity and oropharynx is technically feasible and accurate. There was no false negative sentinel lymph node in our series. 1 Approximately half of all patients who present with oral cavity squamous cell carcinomas (OCSCC) in the developed world are diagnosed with clinical stage I/II OCSCC without clinical or radiological evidence of cervical nodal metastasis. Objectives/hypothesis: Sentinel lymph node biopsy is a minimally invasive method to stage the regional lymphatics that has revolutionized the management of patients with intermediate-thickness cutaneous melanoma. Squamous cell carcinoma is the most common malignancy affecting the oral cavity. Occult metastases were confirmed in 7 sentinel nodes (4 patients). Sentinel lymph node biopsy in head and neck squamous cell carcinoma. Forty sentinel nodes and 276 non-sentinel nodes were histopathologically examined. Also localization with a handheld gamma probe was successful in all patients. Thin serial step sectioning of sentinel lymph node biopsy specimen may not be necessary to accurately stage the neck in oral squamous cell carcinoma J Oral Maxillofac Surg. The histopathological examination of the sentinel nodes and other nodes of neck dissection specimen were compared.ĭetection of sentinel lymph nodes by lymphoscintigraphy was feasible in all 12 patients. The role of sentinel lymph node (SLN) biopsy in these patients remains unclear. After perioperative gamma probe radiolocalization of the sentinel lymph nodes, elective neck dissection was performed. High-risk cutaneous squamous cell carcinoma (SCC) is associated with an increased risk of metastases. Patients preoperatively underwent lymphoscintigraphy after peritumoral injection of a 99m Tc labeled radiocolloid. The aims of the study were to assess our feasibility and accuracy of sentinel lymph node radiolocalization in patients with squamous cell carcinoma of the oral cavity and oropharynx, and to determine whether the pathology of the sentinel node reflected regional disease.
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